Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora: I. Taxonomy, Fermentation, Isolation, and Biological Activities

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent...

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Bibliographic Details
Published in:Journal of antibiotics 1997/09/25, Vol.50(9), pp.734-737
Main Authors: ROMERO, FRANCISCO, ESPLIEGO, FERNANDO, BAZ, JULIA PÉREZ, QUESADA, TERESA GARCÍA DE, GRÁVALOS, DOLORES, CALLE, FERNANDO DE LA, FERNÁNDEZ-PUENTES, JOSÉ LUIS
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Depsipeptides
Fermentation
Fundamental and applied biological sciences. Psychology
Leukemia P388 - drug therapy
Microbial Sensitivity Tests
Microbiology
Micromonospora
Peptides
Tumor Cells, Cultured - drug effects
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Summary:A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.50.734