MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia

The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia (AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor response rate in AML. We have investigated the prognostic value of MDR 1 expression in relation to other patient characteristic...

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Bibliographic Details
Published in:British journal of haematology 1997-10, Vol.99 (1), p.76-83
Main Authors: Van Den Heuvel‐Eibrink, Marry M., Van Der Holt, Bronno, Te Boekhorst, Peter A. W., Pieters, Rob, Schoester, Martijn, Löwenberg, Bob, Sonneveld, Pieter
Format: Article
Language:English
Subjects:
Acute Disease
acute myeloid leukaemia
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD34 - metabolism
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Child
Child, Preschool
Drug Resistance, Multiple - genetics
Female
Genes, MDR
Humans
Infant
Infant, Newborn
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - genetics
Leukemia, Myeloid - metabolism
Male
Medical sciences
Middle Aged
multidrug resistance
Multivariate Analysis
Pharmacology. Drug treatments
Prognosis
prognostic factors
Survival Analysis
Survival Rate
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Summary:The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia (AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor response rate in AML. We have investigated the prognostic value of MDR 1 expression in relation to other patient characteristics with respect to response and survival. One hundred and thirty patients aged 0–88 years were treated for de novo AML with standard induction and consolidation chemotherapy. MDR 1 expression was determined by immunocytochemistry. Univariate and multivariate analyses were conducted to identify prognostic factors for reaching complete remission (CR) and for overall survival from diagnosis, in order to compare MDR 1 with known prognostic factors. Univariate analysis showed that higher MDR 1 expression was an adverse prognostic factor for CR (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1997.3343148.x