Laboratory Studies in Cross‐Species Lung Transplantation

The lack of sufficient suitable human donor lungs for the many patients requiring pulmonary transplantation as life‐saving therapy for end‐stage lung diseases has generated extensive interest in cross‐species lung transplantation. Ethical concerns and those of animal rights advocates have prompted s...

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Bibliographic Details
Published in:World journal of surgery 1997-11, Vol.21 (9), p.951-955
Main Authors: Kamholz, Stephan L., Brewer, Robert J., Grijalva, Galo, Burack, Joshua, Del Rio, Michael J., Vaynblatt, Michael, Lawson, Nuria, Squinto, Steve, Fodor, William L., Norin, Allen J.
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
CD59 Antigens - immunology
Disease Models, Animal
Graft Survival
Humans
Laboratory Study
Lung Disease
Lung Transplantation - immunology
Lung Transplantation - methods
Lung Transplantation - pathology
Organ Donor
Papio
Recent Work
Respiratory Insufficiency - surgery
Solid Organ
Swine
Transplantation, Heterologous - immunology
Transplantation, Heterologous - methods
Transplantation, Heterologous - pathology
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Summary:The lack of sufficient suitable human donor lungs for the many patients requiring pulmonary transplantation as life‐saving therapy for end‐stage lung diseases has generated extensive interest in cross‐species lung transplantation. Ethical concerns and those of animal rights advocates have prompted studies of nonprimate species as potential solid organ donors for humans. This paper provides an overview of some of the laboratory studies of cross‐species pulmonary transplantation performed over the past 20 years and focuses, in particular, on more recent work (from our laboratory and others) in the area of porcine‐to‐primate pulmonary xenotransplantation.
ISSN:0364-2313
1432-2323
DOI:10.1007/s002689900332