Relative and Absolute Configuration of Aloperine

The relative and absolute configuration of the title compound, (6R,7R,9R,11S)-16,17-didehydro-9-de-2-piperidinylormosanine, C15H24N2, has been elucidated. Two X-ray structures, one of the free base of the alkaloid and the second of its dihydrochloride monohydrate salt, C15H26N2(2+).2Cl-.H2O, have be...

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Bibliographic Details
Published in:Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 1997-10, Vol.53 (10), p.1510-1512
Main Authors: Brosius, A. D., Ziller, J. W., Zhang, Q.
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Biological and medical sciences
Crystallography, X-Ray
General pharmacology
Medical sciences
Molecular Structure
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Piperidines
Stereoisomerism
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Summary:The relative and absolute configuration of the title compound, (6R,7R,9R,11S)-16,17-didehydro-9-de-2-piperidinylormosanine, C15H24N2, has been elucidated. Two X-ray structures, one of the free base of the alkaloid and the second of its dihydrochloride monohydrate salt, C15H26N2(2+).2Cl-.H2O, have been determined to unequivocally establish the stereochemistry of aloperine, the parent member of a rare family of lupinine alkaloids.
ISSN:0108-2701
1600-5759
DOI:10.1107/S0108270197009244