Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care

The reliability of a clinical diagnosis of heart failure in primary care is poor. Concentrations of natriuretic peptides are high in heart failure. This population-based study examined the predictive value of natriuretic peptides in patients with a new primary-care diagnosis of heart failure. Concen...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 1997-11, Vol.350 (9088), p.1349-1353
Main Authors: Cowie, Martin R, Struthers, Allan D, Wood, David A, Coats, Andrew JS, Thompson, Simon G, Poole-Wilson, Philip A, Sutton, George C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atrial Natriuretic Factor - blood
Biological and medical sciences
Cardiology. Vascular system
Female
Heart
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Male
Medical sciences
Middle Aged
Peptides
Plasma
Population studies
Primary care
Primary Health Care
Radiography
Radioimmunoassay
Reproducibility of Results
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The reliability of a clinical diagnosis of heart failure in primary care is poor. Concentrations of natriuretic peptides are high in heart failure. This population-based study examined the predictive value of natriuretic peptides in patients with a new primary-care diagnosis of heart failure. Concentrations of plasma atrial (ANP and N-terminal ANP) and B-type (BNP) natriuretic peptides were measured by radioimmunoassay in 122 consecutive patients referred to a rapid-access heart-failure clinic with a new primary-care diagnosis of heart failure. On the basis of clinical assessment, chest radiography, and transthoracic echocardiography, a panel of three cardiologists decided that 35 (29%) patients met the case definition for new heart failure. ANP and NT-ANP results were available for 117 patients (34 with heart failure) and BNP results for 106 (29 with heart failure). Geometric mean concentrations of natriuretic peptides were much higher in patients with heart failure than in those with other diagnoses (29.2 vs 12.4 pmol/L for ANP; 63.9 vs 13.9 pmol/L for BNP; 1187 vs 410.6 pmol/L for NT-ANP; all p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(97)06031-5