The effect of environmental temperature on prandial changes in leucocyte sodium transport in man

Cellular sodium transport via the Na+, K+-ATPase contributes significantly to daily energy expenditure. The effect of a meal on leucocyte Na+ transport and intracellular electrolytes was therefore investigated in lean normal subjects at room temperatures of 23° and 33°, to determine if the Na pump r...

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Bibliographic Details
Published in:British journal of nutrition 1989-11, Vol.62 (3), p.639-645
Main Authors: Ng, L. L., Hockaday, T. D. R.
Format: Article
Language:English
Subjects:
Adult
ATPase
Biological and medical sciences
Biological Transport, Active
Blood Glucose - metabolism
Eating - physiology
Energy Metabolism
Environmental temperature
Fatty Acids, Nonesterified - blood
Female
Fundamental and applied biological sciences. Psychology
Humans
Insulin - blood
Leucocytes
Leukocytes - metabolism
Male
Middle Aged
Sodium - blood
Sodium transport
Temperature
Time Factors
Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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Summary:Cellular sodium transport via the Na+, K+-ATPase contributes significantly to daily energy expenditure. The effect of a meal on leucocyte Na+ transport and intracellular electrolytes was therefore investigated in lean normal subjects at room temperatures of 23° and 33°, to determine if the Na pump responds to the need for thermogenesis. In the fasting state, the ouabain-sensitive efflux rate which reflects active Na+ transport, and the intracellular electrolytes were similar. At 2 h after eating a 4·2 MJ (1000 kcal) meal, the ouabain-sensitive efflux rate constant rose when the room temperature was 23° but not at 33°. The ouabain-sensitive Na+ efflux rate, an index of active Na+ transport, 0rose post-prandially at 23° only. The post-prandial activation of leucocyte active Na efflux in normal subjects was blunted at higher environmental temperatures, when the need for thermogenesis was reduced.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN19890064