Metabolic cooperation in the selection of thioguanine-resistant mutants does not occur with the human B-lymphoblastoid cell TK6

Selection for thioguanine resistant mutants in the human B‐lymphoblastoid cell TK6 yields the same results in both round and flat bottom 96‐well microtiter plates. These results suggest that metabolic cooperation is not an issue in these cells and show that round bottom wells can be used in place of...

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Bibliographic Details
Published in:Environmental and molecular mutagenesis 1997, Vol.30 (3), p.359-361
Main Authors: Gundel, R. M., O'Neill, J. P.
Format: Article
Language:English
Subjects:
B-Lymphocytes
Biological and medical sciences
Cell Line
Cell Separation - methods
Chemical mutagenesis
Drug Resistance
human B-lymphoblastoid cell TK6
Humans
Medical sciences
metabolic cooperation
Mutation
Thioguanine - pharmacology
thioguanine resistant mutants
Toxicology
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Summary:Selection for thioguanine resistant mutants in the human B‐lymphoblastoid cell TK6 yields the same results in both round and flat bottom 96‐well microtiter plates. These results suggest that metabolic cooperation is not an issue in these cells and show that round bottom wells can be used in place of flat bottom wells. Environ. Mol. Mutagen. 30:359–361, 1997. © 1997 Wiley‐Liss, Inc.
ISSN:0893-6692
1098-2280
DOI:10.1002/(SICI)1098-2280(1997)30:3<359::AID-EM16>3.0.CO;2-C