How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies

ESR spectra of spin labels placed at the membrane surface and at different depths of the bilayer core, and melatonin fluorescence in the presence of lipid vesicles, suggest an average shallow position for the hormone in the membrane. However, according to the melatonin ability to cross lipid bilayer...

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Bibliographic Details
Published in:FEBS letters 1997-10, Vol.416 (1), p.103-106
Main Authors: Costa, Ernane J.X, Shida, Claudio S, Biaggi, Márcia H, Ito, Amando S, Lamy-Freund, M.Teresa
Format: Article
Language:English
Subjects:
Dimyristoylphosphatidylcholine - chemistry
Electron Spin Resonance Spectroscopy
Fluorescence
Lipid bilayer
Lipid Bilayers - chemistry
Melatonin
Melatonin - chemistry
Spectrometry, Fluorescence
Spin label
Spin Labels
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Summary:ESR spectra of spin labels placed at the membrane surface and at different depths of the bilayer core, and melatonin fluorescence in the presence of lipid vesicles, suggest an average shallow position for the hormone in the membrane. However, according to the melatonin ability to cross lipid bilayers, nitroxides placed deep in the bilayer were able to quench the melatonin fluorescence. Melatonin membrane partition coefficients were calculated for bilayers in different packing states, and similar and rather high values were found. The data presented here may be quite important to the understanding of melatonin physiological actions at the membrane level.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(97)01178-2