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Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity

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Bibliographic Details
Published in:	Journal of medicinal chemistry 1997-11, Vol.40 (23), p.3707-3711
Main Authors:	Hagen, Susan E, Vara Prasad, J. V. N, Boyer, Frederick E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Markoski, Larry J, Steinbaugh, Bruce A, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, Saunders, James M, VanderRoest, Steven
Format:	Article
Language:	English
Subjects:	AIDS/HIV Animals Anti-HIV Agents - chemical synthesis Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chemical Phenomena Chemistry, Physical HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - enzymology Kinetics Medical sciences Mice Pharmacology. Drug treatments Pyrones - chemical synthesis Pyrones - pharmacokinetics Pyrones - pharmacology Structure-Activity Relationship
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