Recommendations for the biopsy procedure and assessment of skeletal muscle biopsies

Muscle biopsy has a valuable diagnostic role in many neuromuscular diseases, but it is an invasive investigation that should not be undertaken lightly. Furthermore, the biopsy procedure and subsequent laboratory processing of the specimen may significantly influence the results. The following guide...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1997-10, Vol.431 (4), p.227-233
Main Author: ANDERSON, J. R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy - methods
Clinical Laboratory Techniques
Evaluation Studies as Topic
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Muscle, Skeletal - pathology
Osteoarticular system. Muscles
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Specimen Handling - methods
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Summary:Muscle biopsy has a valuable diagnostic role in many neuromuscular diseases, but it is an invasive investigation that should not be undertaken lightly. Furthermore, the biopsy procedure and subsequent laboratory processing of the specimen may significantly influence the results. The following guide is designed to optimise the diagnostic information that can be obtained from muscle biopsy. It covers the whole procedure, from selection of the biopsy site and technique of biopsy, progressing through freezing of the specimen for histochemistry, and the role of immunocytochemistry and electron microscopy. Finally, the contents of a model biopsy report are considered.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050093