CONCENTRATIONS OF ATRACURIUM AND LAUDANOSINE IN CEREBROSPINAL FLUID AND PLASMA DURING INTRACRANIAL SURGERY

Concentrations of atracurium and laudanosine in cerebrospinal fluid (CSF) and plasma were assayed in nine patients receiving atracurium infusions of 111–251 min duration to maintain neuromuscular block during intracranial surgery. The total dose of atracurium was 1.57–2.60 mg kg−1 and the plasma con...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1989-11, Vol.63 (5), p.525-530
Main Authors: EDDLESTION, J.M., HARPER, N.J.N., POLLARD, B.J., EDWARDS, D., GWINNUTT, C.L.
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthetics. Neuromuscular blocking agents
Atracurium - blood
Atracurium - cerebrospinal fluid
Atracurium - pharmacokinetics
Biological and medical sciences
Humans
Intracranial Aneurysm - surgery
Isoquinolines - blood
Isoquinolines - cerebrospinal fluid
Isoquinolines - metabolism
Medical sciences
Middle Aged
Neuropharmacology
Opium - metabolism
Pharmacology. Drug treatments
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Summary:Concentrations of atracurium and laudanosine in cerebrospinal fluid (CSF) and plasma were assayed in nine patients receiving atracurium infusions of 111–251 min duration to maintain neuromuscular block during intracranial surgery. The total dose of atracurium was 1.57–2.60 mg kg−1 and the plasma concentration of atracurium was 1.27–5.44 μg ml−1. Concentrations of laudanosine in CSF and plasma increased during the infusion period, and after 125–140 min reached means of 202.5 ng ml−1 and 1448.7 ng ml−1, respectively. The highest recorded concentration of laudanosine in CSF was 570 ng ml−1, in one of two CSF samples found to contain atracurium. After operation, two patients had fits, but these were not thought to be related to laudanosine. It is concluded that during infusion of atracurium, laudanosine accumulates in both plasma and CSF.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/63.5.525