Involvement of alpha2-adrenergic mechanisms in experimental analgesic and anti-inflammatory activities of a benzamide derivative

Several non-steroidal anti-inflammatory drugs of the N-pyridinyl-benzamide series that produce experimental peripheral and central anti-inflammatory effects possess a dopaminomimetic component and inhibit eicosanoid synthesis without acting directly on the enzymes classically involved in this proces...

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Bibliographic Details
Published in:Pharmacological research 1997-09, Vol.36 (3), p.179-185
Main Authors: Jugé, M, Grimaud, N, Petit, J Y
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Benzamides - pharmacology
Blood Pressure - drug effects
Brain Edema - drug therapy
Brain Edema - physiopathology
Clonidine - pharmacology
Inflammation - drug therapy
Inflammation - physiopathology
Male
Pain Threshold - drug effects
Pain Threshold - physiology
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-2 - drug effects
Receptors, Adrenergic, alpha-2 - physiology
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Summary:Several non-steroidal anti-inflammatory drugs of the N-pyridinyl-benzamide series that produce experimental peripheral and central anti-inflammatory effects possess a dopaminomimetic component and inhibit eicosanoid synthesis without acting directly on the enzymes classically involved in this process. We compared the anti-inflammatory and analgesic activities of one of the most active benzamide derivatives with those of clonidine. Rat paw and brain edemas were inhibited by these two agents, whereas different methods showed that yohimbine counteracted this effect and the analgesia it induced. The involvement of an alpha2-adrenergic and/or serotoninergic components in these activities is considered, without excluding the possibility that the mechanism of action is in part due to inhibition of prostaglandin synthesis.
ISSN:1043-6618