Association of cholinesterases with amyloid in extracellular neurofibrillary tangles

Double-labeling techniques conclusively demonstrated that extracellular neurofibrillary tangles immunoreactive for β protein were also positive for cholinesterases. Ultrastructurally, cholinesterases decorated bundles of amyloid-like filaments, which appeared intermingled with straight filaments and...

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Bibliographic Details
Published in:Brain research 1997-09, Vol.769 (1), p.173-177
Main Authors: Cebrian, J L, Moran, MA, Gomez-Ramos, P
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid
Amyloid beta-Peptides - metabolism
Brain - metabolism
Brain - pathology
Cholinesterases - metabolism
Extracellular Space - metabolism
Humans
Microscopy, Electron
Neurofibrillary degeneration
Neurofibrillary Tangles - metabolism
Neurofibrillary Tangles - pathology
Reference Values
Tangle
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Summary:Double-labeling techniques conclusively demonstrated that extracellular neurofibrillary tangles immunoreactive for β protein were also positive for cholinesterases. Ultrastructurally, cholinesterases decorated bundles of amyloid-like filaments, which appeared intermingled with straight filaments and cellular processes. A lighter labeling of esterases was also seen over most straight filaments. These observations extend the consistent association of cholinesterases with fibrillary β-amyloid protein to a new location in neurofibrillary tangles.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00843-3