Influenza virus vaccination of patients with multiple sclerosis

Prior to vaccination with a trivalent influenza vaccine (AT/Texas, AB/Beijing, and BP/Panama), sera from 19 MS patients had a significantly higher mean level of antibody than 9 normal subjects to AT strain of influenza, but not to AB or BP strains. After Flu vaccination, the mean anti-AT and anti-AB...

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Bibliographic Details
Published in:Multiple sclerosis 1997-08, Vol.3 (4), p.243-247
Main Authors: Mokhtarian, Foroozan, Shirazian, Djamshid, Morgante, Linda, Miller, Aaron, Grob, David, Lichstein, Edgar
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - blood
Antibody Formation
Female
Humans
Influenza A virus - classification
Influenza A virus - immunology
Influenza Vaccines
Influenza, Human - immunology
Influenza, Human - prevention & control
Lymphocyte Activation
Male
Middle Aged
Multiple Sclerosis - immunology
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Summary:Prior to vaccination with a trivalent influenza vaccine (AT/Texas, AB/Beijing, and BP/Panama), sera from 19 MS patients had a significantly higher mean level of antibody than 9 normal subjects to AT strain of influenza, but not to AB or BP strains. After Flu vaccination, the mean anti-AT and anti-AB antibody titers significantly increased 4-fold in I I MS patients and 9 normal subjects. The ratio of MS responders (6II1), however, was lower than normal (8/9). The mean PBL proliferative response to the Flu antigens increased after vaccination significantly more in MS patients than in normal subjects, and increased in 9 of I I MS patients and 3 of 9 normal subjects. Although MS patients responded to Flu antigens with higher antibody levels and proliferative responses of PBL, than normal subjects, a clinical protective effect of the vaccine against Flu was not dearly demonstrated in these patients, and vaccination did not cause or protect against exacerbation of MS.
ISSN:1352-4585
1477-0970
DOI:10.1177/135245859700300405