Targeting of HIV- and SIV-Infected Cells by CD4-Chemokine Receptor Pseudotypes

Retroviral vectors containing CD4 and an appropriate chemokine receptor were evaluated for the ability to transduce cells infected with human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). These CD4-chemokine receptor pseudotypes were able to target HIV- and SIV-infected cell...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1997-11, Vol.278 (5342), p.1462-1464
Main Authors: Endres, Michael J., Jaffer, Salman, Haggarty, Beth, Turner, Julie D., Doranz, Benjamin J., O'Brien, Peter J., Kolson, Dennis L., Hoxie, James A.
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Antiviral agents
Antivirals
Biological and medical sciences
CD4 Antigens - genetics
CD4 Antigens - metabolism
CD4 lymphocytes
Cell Line
Cell lines
Cellular biology
Chemokine receptors
Drug Therapy
Fundamental and applied biological sciences. Psychology
Gene Products, env - metabolism
Gene Transfer Techniques
Genetic Vectors
Genetics
Glycoproteins
Health aspects
HIV
HIV (Viruses)
HIV 1
HIV-1 - physiology
Human immunodeficiency virus
Humans
Macrophages
Macrophages - virology
Medical research
Microbiology
Patients
Plasmids
Receptors
Receptors, CCR5 - genetics
Receptors, CCR5 - metabolism
Receptors, Chemokine - genetics
Receptors, Chemokine - metabolism
Receptors, CXCR4 - genetics
Receptors, CXCR4 - metabolism
Retroviral vectors
simian immunodeficiency virus
Simian Immunodeficiency Virus - physiology
Transfection
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Retroviral vectors containing CD4 and an appropriate chemokine receptor were evaluated for the ability to transduce cells infected with human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). These CD4-chemokine receptor pseudotypes were able to target HIV- and SIV-infected cell lines and monocyte-derived macrophages in a manner that corresponded to the specificity of the viral envelope glycoprotein for its CD4-chemokine receptor complex. This approach could offer a way to deliver antiviral genes directly to HIV-infected cells in vivo and could provide an additional treatment strategy in conjunction with existing antiviral therapies.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.278.5342.1462