Papillary carcinoma of the thyroid with exuberant nodular fasciitis-like stroma

We describe a rare case of papillary carcinoma with extensive proliferation of stromal cells. The stromal cells were immunocytochemically positive for vimentin, alpha-smooth muscle actin and desmin, but negative for cytokeratin, epithelial membrane antigen, S-100, thyroglobulin and CD34. These resul...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1997-10, Vol.431 (4), p.291-295
Main Authors: TERAYAMA, K, TODA, S, YONEMITSU, N, KOIKE, N, SUGIHARA, H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Papillary - metabolism
Carcinoma, Papillary - pathology
Endocrinopathies
Fasciitis - pathology
Female
Fibroblasts - pathology
Humans
Immunohistochemistry
Malignant tumors
Medical sciences
Middle Aged
Muscle, Smooth - pathology
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
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Summary:We describe a rare case of papillary carcinoma with extensive proliferation of stromal cells. The stromal cells were immunocytochemically positive for vimentin, alpha-smooth muscle actin and desmin, but negative for cytokeratin, epithelial membrane antigen, S-100, thyroglobulin and CD34. These results and the ultrastructure of the stromal cells, which exhibited the characteristics of both fibroblasts and smooth muscle cells, indicated an origin from myofibroblasts. We conclude that myofibroblastic proliferation may contribute to the stromal response in the slow growth of the papillary carcinoma.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050101