Regional cerebral blood flow during the wisconsin card sort test in schizotypal personality disorder

Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age-and sex-matched normal volunteers. Subjects performed both the Wisconsin Card Sort Test (WCST) and a control task, the Symbol Matchin...

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Bibliographic Details
Published in:Schizophrenia research 1997-10, Vol.27 (1), p.21-28
Main Authors: Buchsbaum, Monte S., Trestman, Robert L., Hazlett, Erin, Siegel, Benjamin V., Schaefer, Clara H., Luu-Hsia, Christina, Tang, Cheuk, Herrera, Sonya, Solimando, Andrea C., Losonczy, Miklos, Serby, Michael, Silverman, Jeremy, Siever, Larry J.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Attention - physiology
Biological and medical sciences
Brain Mapping
Cerebral Cortex - blood supply
Discrimination Learning - physiology
Dominance, Cerebral - physiology
Frontal lobe
Frontal Lobe - blood supply
Humans
Male
Medical sciences
Middle Aged
Neuropsychological Tests
Neuropsychology
Pattern Recognition, Visual - physiology
Personality disorders
Pilot Projects
Problem Solving - physiology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reference Values
Regional Blood Flow - physiology
Schizophrenia
Schizotypal Personality Disorder - diagnostic imaging
Schizotypal Personality Disorder - physiopathology
Schizotypal Personality Disorder - psychology
Single photon emission computed tomography
Temporal Lobe - blood supply
Tomography, Emission-Computed, Single-Photon
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Summary:Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age-and sex-matched normal volunteers. Subjects performed both the Wisconsin Card Sort Test (WCST) and a control task, the Symbol Matching Test (SMT). Four-way analyses of variance were performed to assess relative rCBF of the prefrontal cortex and of the medial temporal region. Normal volunteers showed more marked activation in the precentral gyrus, while SPD patients showed greater activation in the middle frontal gyrus. Relative flow in the left prefrontal cortex was correlated with better WCST performance in normal volunteers. SPD patients, however, showed no such correlations in the left prefrontal cortex, but demonstrated correlations of good and bad performance with CBF in the right middle and inferior frontal gyrus, respectively. Thus, at least some SPD patients demonstrate abnormal patterns of prefrontal activation, perhaps as a compensation for dysfunction in other regions.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(97)00081-9