Different Babesia canis isolates, different diseases

Using surface immunofluorescence isolate-specific antigens were detected on the membrane of erythrocytes infected with Babesia parasites. In addition, the strains reacted differently with Plasmagel in that the European isolate (B.c. canis) could be purified on Plasmagel effectively, whereas infected...

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Bibliographic Details
Published in:Parasitology 1997-11, Vol.115 (5), p.485-493
Main Authors: SCHETTERS, TH. P. M., MOUBRI, K., PRÉCIGOUT, E., KLEUSKENS, J., SCHOLTES, N. C., GORENFLOT, A.
Format: Article
Language:English
Subjects:
Animals
antigenic diversity
Babesia - pathogenicity
Babesia canis canis
Babesia canis rossi
babesiosis
Babesiosis - epidemiology
Babesiosis - parasitology
Biological and medical sciences
Blood Coagulation
coagulation
Dog Diseases - epidemiology
Dog Diseases - parasitology
Dogs
Erythrocyte Count
Erythrocytes - parasitology
Experimental protozoal diseases and models
Female
France - epidemiology
Infectious diseases
Male
Medical sciences
Parasitic diseases
pathology
Prothrombin Time
Protozoal diseases
South Africa - epidemiology
Species Specificity
Thrombin Time
Travel
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Summary:Using surface immunofluorescence isolate-specific antigens were detected on the membrane of erythrocytes infected with Babesia parasites. In addition, the strains reacted differently with Plasmagel in that the European isolate (B.c. canis) could be purified on Plasmagel effectively, whereas infected erythrocytes of the South-African isolate (B.c. rossi) could not. Experimental infection of dogs with Babesia canis isolates from geographically different areas revealed different pathology. The European isolate obtained from France exhibited transient parasitaemia, usually below 1%, associated with low PCV values and congestion of internal organs. Clinical disease was correlated with an effect on the coagulation system, and not with peripheral parasitaemia. Infection of dogs with South-African-derived isolate induced high parasitaemia usually much higher than 1%, which required chemotherapeutic treatment. In these animals clinical disease was correlated with peripheral parasitaemia and not with parameters of the coagulation system. The results show that the etiology of disease caused by these isolates of B.c. canis and B.c. rossi is different. This might have implications for the development of vaccines against these infections.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182097001686