Immune responses of Leishmania donovani infected BALB/c mice following treatment with free and vesicular sodium stibogluconate formulations

The anti-parasitic efficacy of free and a non-ionic surfactant vesicular (NIV) sodium stibogluconate (SSG) formulation of the drug, and their effect on the immune responses of Leishmania donovani infected BALB/c mice, was compared. The SSG NIV formulation maintained a significant suppression of sple...

Full description

Saved in:
Bibliographic Details
Published in:International journal of immunopharmacology 1997-04, Vol.19 (4), p.195-203
Main Authors: Banduwardene, R., Mullen, A.B., Carter, K.C.
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antibodies, Protozoan - biosynthesis
Antimony Sodium Gluconate - administration & dosage
Antimony Sodium Gluconate - pharmacology
Antiparasitic agents
Antiprotozoal Agents - administration & dosage
Antiprotozoal Agents - pharmacology
BALB/c mouse
Biological and medical sciences
Chemistry, Pharmaceutical
Drug Carriers
Female
immune responses
Interferon-gamma - metabolism
Interleukin-4 - metabolism
Leishmania donovani
Leishmania donovani - immunology
Leishmaniasis, Visceral - immunology
Liver - anatomy & histology
Liver - drug effects
Lymphocyte Activation - drug effects
Male
Medical sciences
Mice
Mice, Inbred BALB C
non-ionic surfactant vesicle
Organ Size - drug effects
Pharmacology. Drug treatments
sodium stibogluconate
Spleen - anatomy & histology
Spleen - drug effects
Spleen - metabolism
Surface-Active Agents - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The anti-parasitic efficacy of free and a non-ionic surfactant vesicular (NIV) sodium stibogluconate (SSG) formulation of the drug, and their effect on the immune responses of Leishmania donovani infected BALB/c mice, was compared. The SSG NIV formulation maintained a significant suppression of splenic, hepatic and bone marrow parasite burdens ( P
ISSN:0192-0561
1879-3495
DOI:10.1016/S0192-0561(97)00009-X