Comparison of Serotonin and Dopamine Release in Substantia Nigra and Ventral Tegmental Area: Region and Species Differences

: In this study, we compare the electrically evoked, somatodendritic release of dopamine (DA) with axonal release of serotonin (5‐HT) in the substantia nigra (SN) and ventral tegmental area (VTA) in vitro by using fast‐scan cyclic voltammetry with carbon‐fibre microelectrodes. Furthermore, we have e...

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Bibliographic Details
Published in:Journal of neurochemistry 1997-12, Vol.69 (6), p.2378-2386
Main Authors: Cragg, S. J., Hawkey, C. R., Greenfield, S. A.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - metabolism
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Dopamine
Dopamine - metabolism
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Male
Mesencephalon - metabolism
Rats
Rats, Wistar
Serotonin
Serotonin - metabolism
Somatodendritic release
Species difference
Species Specificity
Substantia nigra
Substantia Nigra - metabolism
Tegmentum Mesencephali - metabolism
Tissue Distribution
Ventral tegmental area
Vertebrates: nervous system and sense organs
Voltammetry
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Summary:: In this study, we compare the electrically evoked, somatodendritic release of dopamine (DA) with axonal release of serotonin (5‐HT) in the substantia nigra (SN) and ventral tegmental area (VTA) in vitro by using fast‐scan cyclic voltammetry with carbon‐fibre microelectrodes. Furthermore, we have examined transmitter release in these regions in guinea‐pig compared with rat. Somatodendritic DA was released, as shown previously, in guinea‐pig VTA, SN pars compacta (SNc), and occasionally in SN pars reticulata (SNr). 5‐HT was rarely released, except in SNr, where nonetheless it only contributed to
ISSN:0022-3042
1471-4159
DOI:10.1046/j.1471-4159.1997.69062378.x