AIDS and the death receptors

Activation-induced cell death (AICD) of T cells involves the CD95 receptor/ligand system. T cell activation through the T cell receptor results in expression of the CD95 ligand (CD95L) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion. In AIDS, upregulation of CD95L...

Full description

Saved in:
Bibliographic Details
Published in:British medical bulletin 1997, Vol.53 (3), p.604-616
Main Authors: Peter, Marcus E, Ehret, Andreas, Berndt, Christina, Krammer, Peter H
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
AIDS/HIV
Animals
Apoptosis - immunology
fas Receptor - immunology
Genes, tat - immunology
HIV Infections - immunology
HIV-1
Humans
Pan paniscus
Pan troglodytes
Receptors, Tumor Necrosis Factor - immunology
Signal Transduction - immunology
T-Lymphocytes - immunology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Activation-induced cell death (AICD) of T cells involves the CD95 receptor/ligand system. T cell activation through the T cell receptor results in expression of the CD95 ligand (CD95L) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion. In AIDS, upregulation of CD95L in T cells in accelerated by two viral gene products, HIV-1 Tat and gpl20. The CD95 signaling pathways is, therefore, likely to represent an important road to cell death of the CD4+ T cells in AIDS. Recently, the early events in the CD95 signaling pathway have been identified. A key role hereby plays a receptor-interacting member of the interleukin 1β-converting enzymes (ICE), FLICE, that could be a target for therapeutic intervention. In addition to CD95, the role of other members of the TNF receptor superfamily in AIDS is discussed.
ISSN:0007-1420
1471-8391
DOI:10.1093/oxfordjournals.bmb.a011633