Spectrophotometric determination of penicilloates in penicillins

A procedure has been developed for the determination of penicilloates based on the reduction of CuII and detection of CuI using neocuproine. The sensitivity range is 5.6-56 microns penicilloate and the standard deviation was found to be between 1 and 2%. All the penicilloates tested reduced CuII und...

Full description

Saved in:
Bibliographic Details
Published in:Analyst (London) 1989-09, Vol.114 (9), p.1137-1139
Main Author: Baker, W L
Format: Article
Language:English
Subjects:
Copper
Oxidation-Reduction
Penicillanic Acid - analysis
Penicillins - analysis
Phenanthrolines
Spectrophotometry
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A procedure has been developed for the determination of penicilloates based on the reduction of CuII and detection of CuI using neocuproine. The sensitivity range is 5.6-56 microns penicilloate and the standard deviation was found to be between 1 and 2%. All the penicilloates tested reduced CuII under the conditions of the assay and a slight modification allowed a reasonably accurate determination of the level of this biologically inactive ingredient in a mixture with the parent penicillin. The deterioration of solutions of benzylpenicillin was also studied.
ISSN:0003-2654
1364-5528
DOI:10.1039/AN9891401137