Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death

Some randomized clinical trials of amiodarone therapy to prevent sudden cardiac death have had positive results and others have had negative results, but all were relatively small. This meta-analysis aimed to pool all trials to assess the effect of amiodarone on mortality and the impact of differenc...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1997-11, Vol.96 (9), p.2823-2829
Main Authors: SIM, I, MCDONALD, K. M, LAVORI, P. W, NORBUTAS, C. M, HLATKY, M. A
Format: Article
Language:English
Subjects:
Aged
Amiodarone - therapeutic use
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
Biological and medical sciences
Cardiovascular system
Death, Sudden - prevention & control
Female
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Randomized Controlled Trials as Topic
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Summary:Some randomized clinical trials of amiodarone therapy to prevent sudden cardiac death have had positive results and others have had negative results, but all were relatively small. This meta-analysis aimed to pool all trials to assess the effect of amiodarone on mortality and the impact of differences in patient population and study design on trial outcomes. Fifteen randomized trials were identified, and outcome measures were combined by use of a random effects model. The effect of patient population and study design on total mortality was assessed by use of a hierarchical Bayes model. Amiodarone reduced total mortality by 19% (confidence limits, 6% to 31%; P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.96.9.2823