Ion-Selective Electrodes for Promethazine Determinations in Pharmaceutical Preparations and Application to Flow Injection Analysis

The construction and evaluation of PM-selective electrodes with a conventional configuration and without internal reference solution are described. Two different PVC membranes were prepared with PM tetraphenylborate dissolved in 2-nitrophenyl octyl ether (type A) or bis(2- ethylhexyl)sebacate (type...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1997-11, Vol.86 (11), p.1234-1238
Main Authors: Jose, L.F., Lima, C., Conceiçao, M., Montenegro, B.S.M., Goreti, M., Sales, F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Electrodes
Flow Injection Analysis
Histamine and antagonists. Allergy
Histamine H1 Antagonists - analysis
Medical sciences
Pharmacology. Drug treatments
Promethazine - analysis
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Summary:The construction and evaluation of PM-selective electrodes with a conventional configuration and without internal reference solution are described. Two different PVC membranes were prepared with PM tetraphenylborate dissolved in 2-nitrophenyl octyl ether (type A) or bis(2- ethylhexyl)sebacate (type B). When the electrodes were evaluated in 0.01M ionic strength solutions, both presented linear responses from 5 X 10−5 to 1 X 10−2M, slopes close to the theoretical value, practical detection limits of ~2 x 10−5M, reproducibilities of ±0.2mV/day, and a quick response (
ISSN:0022-3549
1520-6017
DOI:10.1021/js970171a