Predictive factors of survival and intrahepatic recurrence of hepatocellular carcinoma in cirrhosis after percutaneous ethanol injection: analysis of 71 patients

Background/Aims: This study was undertaken to determine the factors predicting survival and intrahepatic recurrence in hepatocellular carcinoma patients treated with percutaneous ethanol injection. Methods: Seventy-one patients with cirrhosis and hepatocellular carcinoma underwent percutaneous ethan...

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Bibliographic Details
Published in:Journal of hepatology 1997-11, Vol.27 (5), p.862-870
Main Authors: Castellano, Luigi, Calandra, Maria, Blanco, Camillo Del Vecchio, de Sio, Ilario
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Digestive system
Ethanol - administration & dosage
Ethanol - therapeutic use
Female
Follow-Up Studies
Hepatocellular carcinoma
Humans
Liver Cirrhosis - mortality
Liver Cirrhosis - pathology
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Male
Medical sciences
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Percutaneous ethanol injection
Pharmacology. Drug treatments
Prognosis
Prognostic factors
Recurrence
Survival
Survival Rate
Treatment Outcome
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Summary:Background/Aims: This study was undertaken to determine the factors predicting survival and intrahepatic recurrence in hepatocellular carcinoma patients treated with percutaneous ethanol injection. Methods: Seventy-one patients with cirrhosis and hepatocellular carcinoma underwent percutaneous ethanol injection (54 males/17 females; median age 66 years; Child a 54/B 17). Fifty-two patients had a single nodule ≤5 cm and 19 had multiple nodules, up to three, each one ≤4 cm. Follow-up ranged from 2–63 months (median 26). Results: Overall survival rates were 89%, 54% and 24% and new lesions recurrence rates 32%, 73% and 81% at 1, 3 and 5 years, respectively. At univariate analysis, monofocal tumor ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(97)80324-8