The Short‐Term Effects of Cisplatin Chemotherapy on Bone Turnover

Cisplatin is an effective agent in the treatment of osteosarcoma of bone but little is known of its effects on normal bone turnover. Twenty‐four dogs divided into three study groups were used to study the effect of cisplatin on normal bone turnover at the distant site of surgery. Group 1 served as t...

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Bibliographic Details
Published in:Journal of bone and mineral research 1997-11, Vol.12 (11), p.1874-1882
Main Authors: Young, David R., Virolainen, Petri, Inoue, Nozomu, Frassica, Frank J., Chao, Edmund Y. S.
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
Antineoplastic Agents - pharmacology
Biological and medical sciences
Biomarkers - blood
Biomarkers - urine
Bone Remodeling - drug effects
Cell physiology
Cisplatin - administration & dosage
Cisplatin - pharmacokinetics
Cisplatin - pharmacology
Diaphyses - drug effects
Dogs
Femur - cytology
Femur - drug effects
Femur - surgery
Fundamental and applied biological sciences. Psychology
Male
Mineralization, calcification
Molecular and cellular biology
Osteocalcin - blood
Perioperative Care
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Summary:Cisplatin is an effective agent in the treatment of osteosarcoma of bone but little is known of its effects on normal bone turnover. Twenty‐four dogs divided into three study groups were used to study the effect of cisplatin on normal bone turnover at the distant site of surgery. Group 1 served as the control group, group 2 received four cycles of cisplatin every 3 weeks before the surgery, and group 3 received four cycles postoperatively. The bone turnover rate was evaluated by measuring levels of systemic bone markers, osteocalcin, alkaline phospohatase, urine pyridinoline cross‐links, and by determination histomorphometric indices. Histomorphological analysis showed poor correlation on bone formation with systemic bone markers at distant sites of surgery. Histomorphometrically normal bone turnover was affected by administration of cisplatin, but the effect was temporary, late, and less significant than what occurred at the surgical site. Our data showed that significant effects of cisplatin are observed at the site of active cellular induction and proliferation, such as implant‐host interface, and less effects are seen at the sites of normal bone turnover.
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.1997.12.11.1874