The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer

• Published in: BJOG : an international journal of obstetrics and gynaecology 1997-11, Vol.104 (11), p.1314-1319
• Main Authors: Sheu, Bor‐Ching, Lin, Ho‐Hsiung, Chang, Daw‐Yuan, Ho, Hong‐Nerng, Huang, Su‐Cheng
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Biomarkers, Tumor - blood; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Genital system. Mammary gland; Humans; Investigative techniques, diagnostic techniques (general aspects); Leiomyoma - blood; Leiomyoma - diagnosis; Medical sciences; Middle Aged; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prospective Studies; Receptors, Tumor Necrosis Factor - blood; Tropical medicine; Uterine Cervical Neoplasms - blood; Uterine Cervical Neoplasms - diagnosis; Uterine Neoplasms - blood; Uterine Neoplasms - diagnosis
• ISSN: 1470-0328; 0306-5456; 1471-0528; 1365-215X
• DOI: 10.1111/j.1471-0528.1997.tb10981.x

Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF‐RI) as a potential biochemical marker in women with cervical cancer. Design A prospective, case‐controlled study. Participants Seventy‐one women with cervical cancer and 33 women with myoma were enrolled in this study. Methods Pre‐operative serum levels of sTNF‐RI were measured with a standard enzyme‐linked immunosorbent assay utilising murine monoclonal antibody against sTNF‐RI. Main outcome measures All data in both groups were evaluated and correlated with the pre‐operative serum levels of sTNF‐RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression. Results The mean serum level of sTNF‐RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF‐RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF‐RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF‐RI and tumour size (r=−0.622, P < 0.0001). Conclusions Decreased pre‐operative serum levels of sTNF‐RI are observed in women with cervical cancer. The results do not support that the use of sTNF‐RI as a biochemical marker for cervical cancer.