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The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer
Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF‐RI) as a potential biochemical marker in women with cervical cancer. Design A prospective, case‐controlled study. Participants Seventy‐one women with cervical cancer and 33 women with myoma...
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| Published in: | BJOG : an international journal of obstetrics and gynaecology 1997-11, Vol.104 (11), p.1314-1319 |
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| Language: | English |
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| container_end_page | 1319 |
| container_issue | 11 |
| container_start_page | 1314 |
| container_title | BJOG : an international journal of obstetrics and gynaecology |
| container_volume | 104 |
| creator | Sheu, Bor‐Ching Lin, Ho‐Hsiung Chang, Daw‐Yuan Ho, Hong‐Nerng Huang, Su‐Cheng |
| description | Objectives
To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF‐RI) as a potential biochemical marker in women with cervical cancer.
Design
A prospective, case‐controlled study.
Participants
Seventy‐one women with cervical cancer and 33 women with myoma were enrolled in this study.
Methods
Pre‐operative serum levels of sTNF‐RI were measured with a standard enzyme‐linked immunosorbent assay utilising murine monoclonal antibody against sTNF‐RI.
Main outcome measures
All data in both groups were evaluated and correlated with the pre‐operative serum levels of sTNF‐RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.
Results
The mean serum level of sTNF‐RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF‐RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF‐RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF‐RI and tumour size (r=−0.622, P < 0.0001).
Conclusions
Decreased pre‐operative serum levels of sTNF‐RI are observed in women with cervical cancer. The results do not support that the use of sTNF‐RI as a biochemical marker for cervical cancer. |
| doi_str_mv | 10.1111/j.1471-0528.1997.tb10981.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79434957</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79434957</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3994-af23e8ed4126a3c76a978a6103c0845f387a7e98a04136c86b6e5144ffdb8f683</originalsourceid><addsrcrecordid>eNqVkM1u3CAUhVHVKE2TPkIlVFXd2QGDMXRTpVF_EkXKJl0jzFwUpthMwU6Tty-esWZfNhw4514uH0IfKKlpWZfbmvKOVqRtZE2V6uqpp0RJWj-_QmdH6_Vek4qwRr5Bb3PeEkJFQ9gpOlVMCsLaMzQ_PALexQnGyZuAo8MZ0jzgAE8Q8v4cw9wHwNM8xDnhEWyK2WfsjJ1iwgks7BZxg03GBvc-2kcYvC3dBpN-Q8J-xBbS0_7KmrHoC3TiTMjwbt3P0a_v3x6uf1Z39z9urq_uKsuU4pVxDQMJG04bYZjthFGdNIISZonkrWOyMx0oaQinTFgpegEt5dy5TS-dkOwcfTr03aX4Z4Y86cFnCyGYEeKcdac446rtSvDzIbh8Lidwepd8Gf9FU6IX5nqrF7B6AasX5nplrp9L8fv1lbkfYHMsXSEX_-Pqm1wYuFQY-HyMNYQrwVWJfTnE_voAL_8xgP56e08Z5ewfrSKfaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79434957</pqid></control><display><type>article</type><title>The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Sheu, Bor‐Ching ; Lin, Ho‐Hsiung ; Chang, Daw‐Yuan ; Ho, Hong‐Nerng ; Huang, Su‐Cheng</creator><creatorcontrib>Sheu, Bor‐Ching ; Lin, Ho‐Hsiung ; Chang, Daw‐Yuan ; Ho, Hong‐Nerng ; Huang, Su‐Cheng</creatorcontrib><description>Objectives
To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF‐RI) as a potential biochemical marker in women with cervical cancer.
Design
A prospective, case‐controlled study.
Participants
Seventy‐one women with cervical cancer and 33 women with myoma were enrolled in this study.
Methods
Pre‐operative serum levels of sTNF‐RI were measured with a standard enzyme‐linked immunosorbent assay utilising murine monoclonal antibody against sTNF‐RI.
Main outcome measures
All data in both groups were evaluated and correlated with the pre‐operative serum levels of sTNF‐RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.
Results
The mean serum level of sTNF‐RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF‐RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF‐RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF‐RI and tumour size (r=−0.622, P < 0.0001).
Conclusions
Decreased pre‐operative serum levels of sTNF‐RI are observed in women with cervical cancer. The results do not support that the use of sTNF‐RI as a biochemical marker for cervical cancer.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>EISSN: 1365-215X</identifier><identifier>DOI: 10.1111/j.1471-0528.1997.tb10981.x</identifier><identifier>PMID: 9386035</identifier><identifier>CODEN: BJOGAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Genital system. Mammary gland ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leiomyoma - blood ; Leiomyoma - diagnosis ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prospective Studies ; Receptors, Tumor Necrosis Factor - blood ; Tropical medicine ; Uterine Cervical Neoplasms - blood ; Uterine Cervical Neoplasms - diagnosis ; Uterine Neoplasms - blood ; Uterine Neoplasms - diagnosis</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 1997-11, Vol.104 (11), p.1314-1319</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3994-af23e8ed4126a3c76a978a6103c0845f387a7e98a04136c86b6e5144ffdb8f683</citedby><cites>FETCH-LOGICAL-c3994-af23e8ed4126a3c76a978a6103c0845f387a7e98a04136c86b6e5144ffdb8f683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2049649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9386035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheu, Bor‐Ching</creatorcontrib><creatorcontrib>Lin, Ho‐Hsiung</creatorcontrib><creatorcontrib>Chang, Daw‐Yuan</creatorcontrib><creatorcontrib>Ho, Hong‐Nerng</creatorcontrib><creatorcontrib>Huang, Su‐Cheng</creatorcontrib><title>The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>Objectives
To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF‐RI) as a potential biochemical marker in women with cervical cancer.
Design
A prospective, case‐controlled study.
Participants
Seventy‐one women with cervical cancer and 33 women with myoma were enrolled in this study.
Methods
Pre‐operative serum levels of sTNF‐RI were measured with a standard enzyme‐linked immunosorbent assay utilising murine monoclonal antibody against sTNF‐RI.
Main outcome measures
All data in both groups were evaluated and correlated with the pre‐operative serum levels of sTNF‐RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.
Results
The mean serum level of sTNF‐RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF‐RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF‐RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF‐RI and tumour size (r=−0.622, P < 0.0001).
Conclusions
Decreased pre‐operative serum levels of sTNF‐RI are observed in women with cervical cancer. The results do not support that the use of sTNF‐RI as a biochemical marker for cervical cancer.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Case-Control Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leiomyoma - blood</subject><subject>Leiomyoma - diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prospective Studies</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Tropical medicine</subject><subject>Uterine Cervical Neoplasms - blood</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - blood</subject><subject>Uterine Neoplasms - diagnosis</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqVkM1u3CAUhVHVKE2TPkIlVFXd2QGDMXRTpVF_EkXKJl0jzFwUpthMwU6Tty-esWZfNhw4514uH0IfKKlpWZfbmvKOVqRtZE2V6uqpp0RJWj-_QmdH6_Vek4qwRr5Bb3PeEkJFQ9gpOlVMCsLaMzQ_PALexQnGyZuAo8MZ0jzgAE8Q8v4cw9wHwNM8xDnhEWyK2WfsjJ1iwgks7BZxg03GBvc-2kcYvC3dBpN-Q8J-xBbS0_7KmrHoC3TiTMjwbt3P0a_v3x6uf1Z39z9urq_uKsuU4pVxDQMJG04bYZjthFGdNIISZonkrWOyMx0oaQinTFgpegEt5dy5TS-dkOwcfTr03aX4Z4Y86cFnCyGYEeKcdac446rtSvDzIbh8Lidwepd8Gf9FU6IX5nqrF7B6AasX5nplrp9L8fv1lbkfYHMsXSEX_-Pqm1wYuFQY-HyMNYQrwVWJfTnE_voAL_8xgP56e08Z5ewfrSKfaA</recordid><startdate>199711</startdate><enddate>199711</enddate><creator>Sheu, Bor‐Ching</creator><creator>Lin, Ho‐Hsiung</creator><creator>Chang, Daw‐Yuan</creator><creator>Ho, Hong‐Nerng</creator><creator>Huang, Su‐Cheng</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199711</creationdate><title>The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer</title><author>Sheu, Bor‐Ching ; Lin, Ho‐Hsiung ; Chang, Daw‐Yuan ; Ho, Hong‐Nerng ; Huang, Su‐Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3994-af23e8ed4126a3c76a978a6103c0845f387a7e98a04136c86b6e5144ffdb8f683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Case-Control Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leiomyoma - blood</topic><topic>Leiomyoma - diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prospective Studies</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Tropical medicine</topic><topic>Uterine Cervical Neoplasms - blood</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Neoplasms - blood</topic><topic>Uterine Neoplasms - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheu, Bor‐Ching</creatorcontrib><creatorcontrib>Lin, Ho‐Hsiung</creatorcontrib><creatorcontrib>Chang, Daw‐Yuan</creatorcontrib><creatorcontrib>Ho, Hong‐Nerng</creatorcontrib><creatorcontrib>Huang, Su‐Cheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheu, Bor‐Ching</au><au>Lin, Ho‐Hsiung</au><au>Chang, Daw‐Yuan</au><au>Ho, Hong‐Nerng</au><au>Huang, Su‐Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1997-11</date><risdate>1997</risdate><volume>104</volume><issue>11</issue><spage>1314</spage><epage>1319</epage><pages>1314-1319</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>Objectives
To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF‐RI) as a potential biochemical marker in women with cervical cancer.
Design
A prospective, case‐controlled study.
Participants
Seventy‐one women with cervical cancer and 33 women with myoma were enrolled in this study.
Methods
Pre‐operative serum levels of sTNF‐RI were measured with a standard enzyme‐linked immunosorbent assay utilising murine monoclonal antibody against sTNF‐RI.
Main outcome measures
All data in both groups were evaluated and correlated with the pre‐operative serum levels of sTNF‐RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.
Results
The mean serum level of sTNF‐RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF‐RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF‐RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF‐RI and tumour size (r=−0.622, P < 0.0001).
Conclusions
Decreased pre‐operative serum levels of sTNF‐RI are observed in women with cervical cancer. The results do not support that the use of sTNF‐RI as a biochemical marker for cervical cancer.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9386035</pmid><doi>10.1111/j.1471-0528.1997.tb10981.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 1997-11, Vol.104 (11), p.1314-1319 |
| issn | 1470-0328 0306-5456 1471-0528 1365-215X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79434957 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biological and medical sciences Biomarkers, Tumor - blood Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Genital system. Mammary gland Humans Investigative techniques, diagnostic techniques (general aspects) Leiomyoma - blood Leiomyoma - diagnosis Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prospective Studies Receptors, Tumor Necrosis Factor - blood Tropical medicine Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - diagnosis Uterine Neoplasms - blood Uterine Neoplasms - diagnosis |
| title | The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer |
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