Left ventricular pressure-volume relationships before and after cardiomyoplasty in patients with heart failure

The aim of this study was to elucidate whether beneficial effects of cardiomyoplasty (CMP) in patients with dilated cardiomyopathy are the result of a decrease in existing ventricular dilatation or a prevention of further dilatation. Combined micromanometer-conductance catheters were used to evaluat...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1997-11, Vol.96 (9), p.2978-2986
Main Authors: SCHREUDER, J. J, VAN DER VEEN, F. H, VOLTERRANI, M, KAULBACH, H.-G, BAAN, J, WELLENS, H. J. J, VAN DER VELDE, E. T, DELAHAYE, F, ALFIERI, O, JEGADEN, O, LORUSSO, R, JANSEN, J. R. C, HOEKSEL, S. A. A. P, FINET, G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Dilated - physiopathology
Cardiomyopathy, Dilated - surgery
Cardiomyoplasty
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics - drug effects
Humans
Medical sciences
Middle Aged
Nitroglycerin - pharmacology
Ventricular Function, Left
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Summary:The aim of this study was to elucidate whether beneficial effects of cardiomyoplasty (CMP) in patients with dilated cardiomyopathy are the result of a decrease in existing ventricular dilatation or a prevention of further dilatation. Combined micromanometer-conductance catheters were used to evaluate left ventricular pressure-volume relationships in six patients with dilated cardiomyopathy before and at 6 and 12 months after CMP. Acute changes in preload and afterload were induced by a standardized leg-tilting intervention and a bolus infusion of nitroglycerin. After CMP, end-diastolic volume (EDV) decreased from 138+/-10 to 103+/-18 mL/m2 (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.96.9.2978