Interventions for Perinatal Hypoxic-Ischemic Encephalopathy

Vannucci and Perlman discuss the characteristics of hypoxic-ischemic brain damage in newborn infants. Calcium channel blockers, inhibitors of nitric oxide production and excitatory amino acid antagonists are some pharmacologic agents being investigated for hypoxic-ischemic encephalopathy.

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Bibliographic Details
Published in:Pediatrics (Evanston) 1997-12, Vol.100 (6), p.1004-1014
Main Authors: Vannucci, Robert C, Perlman, Jeffrey M
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Antioxidants
Antioxidants (Nutrients)
Asphyxia neonatorum
Asphyxia Neonatorum - complications
Asphyxia Neonatorum - therapy
Babies
Biological and medical sciences
Brain damage
Brain Damage, Chronic - prevention & control
Brain Ischemia - complications
Brain Ischemia - therapy
Calcium Channel Blockers - therapeutic use
Complications and side effects
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Encephalopathy
Excitatory Amino Acid Antagonists - therapeutic use
Fetal Hypoxia - complications
Free Radical Scavengers - therapeutic use
Free Radicals - antagonists & inhibitors
Health aspects
Humans
Hypothermia, Induced
Hypoxia, Brain - complications
Hypoxia, Brain - therapy
Infant, Newborn
Intensive care medicine
Medical sciences
Nitric Oxide - antagonists & inhibitors
Pediatrics
Pharmaceuticals
Phenobarbital - therapeutic use
Prevention
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Description
Summary:Vannucci and Perlman discuss the characteristics of hypoxic-ischemic brain damage in newborn infants. Calcium channel blockers, inhibitors of nitric oxide production and excitatory amino acid antagonists are some pharmacologic agents being investigated for hypoxic-ischemic encephalopathy.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.100.6.1004