Inescapable Shock-Induced Potentiation of Morphine Analgesia

Exposure to various stressors potentiates nociceptive and nonnociceptive responses to morphine. These phenomena have received little study despite their seeming generality and importance for understanding analgesia and opiate action. The present experiments characterize inescapable shock (IS)-induce...

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Bibliographic Details
Published in:Behavioral neuroscience 1997-10, Vol.111 (5), p.1105-1113
Main Authors: Sutton, Lorraine C, Lea, S. Elizabeth, Will, Matthew J, Schwartz, Boyd A, Hartley, Chad E, Poole, Jason C, Watkins, Linda R, Maier, Steven F
Format: Article
Language:English
Subjects:
Analgesia
Analgesics, Opioid - pharmacology
Animal
Animal behavior
Animals
Arousal - drug effects
Arousal - physiology
Behavioral psychophysiology
Biological and medical sciences
Electroshock
Escape Reaction - drug effects
Escape Reaction - physiology
Fundamental and applied biological sciences. Psychology
Helplessness, Learned
Male
Miscellaneous
Morphine
Morphine - pharmacology
Narcotics
Nociceptors - drug effects
Nociceptors - physiology
Pain Threshold - drug effects
Pain Threshold - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Reaction Time - drug effects
Reaction Time - physiology
Restraint, Physical
Rodents
Shock
Stimulus Variability
Thermosensing - drug effects
Thermosensing - physiology
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Summary:Exposure to various stressors potentiates nociceptive and nonnociceptive responses to morphine. These phenomena have received little study despite their seeming generality and importance for understanding analgesia and opiate action. The present experiments characterize inescapable shock (IS)-induced potentiation of morphine analgesia. Rats were exposed to IS, equal escapable shocks (ESs), or restraint (control). Potentiation of analgesia (tail-flick [TF] test and hotplate test) was observed only in rats given IS 24 or 48 hr earlier, in agreement with previously reported learned-helplessness effects. Finally, no change in tail temperature or motor function was found that could be inaccurately interpreted as analgesia. The relevance of these findings to stressor-induced enhancement of morphine analgesia and potential substrates of IS effects are discussed.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.111.5.1105