Developmental signaling: notch signals Kuz it's cleaved

Recent experiments with Kuzbanian, a disintegrin metalloprotease that is required during development for lateral inhibitory signaling, suggest that signaling molecules of the Notch family may guide cell fate only after they are activated by proteolysis, and that the proteolysis may be catalyzed by K...

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Bibliographic Details
Published in:Current biology 1997-11, Vol.7 (11), p.R716-R720
Main Author: Nye, J S
Format: Article
Language:English
Subjects:
Disintegrins - genetics
Disintegrins - metabolism
Disintegrins - physiology
Drosophila Proteins
Gene Expression Regulation, Developmental
Hydrolysis
Membrane Proteins - genetics
Membrane Proteins - metabolism
Membrane Proteins - physiology
Metalloendopeptidases - genetics
Metalloendopeptidases - metabolism
Metalloendopeptidases - physiology
Receptors, Notch
Signal Transduction - genetics
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Summary:Recent experiments with Kuzbanian, a disintegrin metalloprotease that is required during development for lateral inhibitory signaling, suggest that signaling molecules of the Notch family may guide cell fate only after they are activated by proteolysis, and that the proteolysis may be catalyzed by Kuzbanian.
ISSN:0960-9822
DOI:10.1016/s0960-9822(06)00364-2