Multistep Control of Pituitary Organogenesis

Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1997-12, Vol.278 (5344), p.1809-1812
Main Authors: Sheng, Hui Z., Moriyama, Kenji, Yamashita, Tsuyoshi, Li, Hung, Potter, S. Steven, Mahon, Kathleen A., Westphal, Heiner
Format: Article
Language:English
Subjects:
Animals
Antibodies
Biological and medical sciences
Cell Differentiation
Cell Division
Cell growth
Cell Lineage
Cell lines
Cellular biology
Classical genetics, quantitative genetics, hybrids
Developmental biology
Developmental genetics
Embryonic and Fetal Development - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Genes
Genes, Homeobox
Genetic aspects
Genetic mutation
Genetics of eukaryotes. Biological and molecular evolution
Homeodomain Proteins - genetics
Homeodomain Proteins - physiology
Hormones
Individualized Instruction
LIM-Homeodomain Proteins
Mice
Mutation
Organogenesis
Pituitary gland
Pituitary Gland - chemistry
Pituitary Gland - cytology
Pituitary Gland - embryology
Pituitary Hormones - analysis
Pituitary Hormones - genetics
Pregnancy
Rodents
Stem cells
Stem Cells - cytology
Transcription Factors
Transcripts (Written Records)
Vertebrata
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Description
Summary:Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.278.5344.1809