A pilot study on upper esophageal sphincter dilatation for the treatment of dysphagia in patients with oculopharyngeal muscular dystrophy

Upper esophageal sphincter (UES) dilatation was done for the treatment of moderate to severe dysphagia with a Maloney bougie in 14 patients with oculopharyngeal muscular dystrophy (OPMD) or with an achalasia dilator in three patients. The severity of dysphagia prior to UES dilatation was evaluated b...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 1997-10, Vol.7, p.S100-S104
Main Authors: Mathieu, Jean, Lapointe, Gilles, Brassard, Anne, Tremblay, Carmen, Brais, Bernard, Rouleau, Guy A., Bouchard, Jean-Pierre
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Deglutition Disorders - etiology
Deglutition Disorders - surgery
Dilatation
Dysphagia
Esophageal dilatation
Esophagogastric Junction - surgery
Female
Humans
Male
Manometry
Middle Aged
Muscular Dystrophies - complications
Muscular dystrophy
Oculomotor Muscles
Pharyngeal Muscles
Pilot Projects
Surgical Instruments
Surgical Procedures, Operative - methods
Treatment Outcome
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Summary:Upper esophageal sphincter (UES) dilatation was done for the treatment of moderate to severe dysphagia with a Maloney bougie in 14 patients with oculopharyngeal muscular dystrophy (OPMD) or with an achalasia dilator in three patients. The severity of dysphagia prior to UES dilatation was evaluated by a 15-point dysphagia score, a pharyngeal and esophageal manometry and a radionuclide pharyngoesophageal transit study. Using actuarial life table, the improvement rate after dilatation with Maloney bougie was 64.3% (95% CI 39.2–89.4) at 3- and 6-month follow-ups, and was 55.7% (95% CI 28.9–82.5) at 12- and 18-month follow-ups. At 3-month post-dilatation, we observed a significant reduction of the mean dysphagia score from 9.6 to 7.2 ( P = 0.05). No signi were found to predict effective dilatation. The results of this pilot study showed that UES dilatation with Maloney bougie or achalasia dilator may be an effective treatment of moderate dysphagia in patients with OPMD. However, further studies with larger sample sizes are needed to corroborate these results and to assess long-term outcome.
ISSN:0960-8966
1873-2364
DOI:10.1016/S0960-8966(97)00092-8