Effect of endotoxin administration on the severity of acute pancreatitis in two experimental models

Endotoxemia can transform acute pancreatitis (AP) into a more severe form of the disease in models of AP provoked by common pancreatico-biliary duct ligation or L-arginine injection. It has been shown that systemic endotoxemia is a common feature in severe AP. The effect of endotoxemia on the course...

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Bibliographic Details
Published in:International journal of gastrointestinal cancer 1997-08, Vol.22 (1), p.31-37
Main Authors: POZSAR, J, SCHWAB, R, SIMON, K, FEKETE, L, ORGOVAN, G, PAP, A
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Biological and medical sciences
Disease Models, Animal
Endotoxemia - complications
Endotoxemia - etiology
Endotoxemia - mortality
Endotoxemia - pathology
Endotoxins - administration & dosage
Gastroenterology. Liver. Pancreas. Abdomen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Other diseases. Semiology
Pancreatitis - complications
Pancreatitis - mortality
Pancreatitis - pathology
Rats
Rats, Wistar
Survival Rate
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Summary:Endotoxemia can transform acute pancreatitis (AP) into a more severe form of the disease in models of AP provoked by common pancreatico-biliary duct ligation or L-arginine injection. It has been shown that systemic endotoxemia is a common feature in severe AP. The effect of endotoxemia on the course of experimental pancreatitis is unknown. AP was induced by common pancreatico-biliary duct ligation (experiment 1) and i.p. injection of 250 mg/100 g body wt of L-arginine (experiment 2). Test animals of both experiments received i.p. injections of 0.5 and 1.0 mg/100 g body wt of endotoxin at the induction of AP. Saline-treated and only endotoxin-dosed animals served as controls for both experiments. Mortality rates and pancreatic histology were investigated at 48 h. The mortality rate was significantly elevated (60%, p < 0.05) in experiment 1 when 1.0 mg/100 g of endotoxin was given. In experiment 2, the mortality rate was also increased (30%) at this dose of endotoxin without reaching significance. Histologic changes were more severe in both groups of AP treated by the two doses of endotoxin than without it. Acinar necrosis and hemorrhage were highly elevated (p < 0.01) in both experiments when AP was combined with 1.0 mg/100 g body wt of endotoxin. The animals receiving only endotoxin showed only slight inflammatory and necrotic changes.
ISSN:0169-4197
1537-3649
1559-0739
DOI:10.1007/BF02803902