Diltiazem and Pentoxifylline Determination in Postmortem Specimens

A 78-year-old woman was found dead in her basement. Qualitative screening of available postmortem specimens detected the presence of diltiazem and pentoxifylline. Quantitations were carried out by gas chromatography using nitrogen-phosphorus detection and confirmed by gas chromatography-mass spectro...

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Bibliographic Details
Published in:Journal of analytical toxicology 1997-11, Vol.21 (7), p.576-579
Main Authors: Engelhart, David A., Lavins, Eric S., Seligman, Stanley S., Sutheimer, Craig A.
Format: Article
Language:English
Subjects:
Aged
Bile - chemistry
Biological and medical sciences
Calcium Channel Blockers - analysis
Calcium Channel Blockers - blood
Calcium Channel Blockers - urine
Diltiazem - analysis
Diltiazem - blood
Diltiazem - urine
Drug intoxications. Doping
Female
Gas Chromatography-Mass Spectrometry
Gastrointestinal Contents - chemistry
Humans
Liver - chemistry
Medical sciences
Pentoxifylline - analysis
Pharmacology. Drug treatments
Tissue Distribution
Vasodilator Agents - analysis
Vitreous Body - chemistry
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Summary:A 78-year-old woman was found dead in her basement. Qualitative screening of available postmortem specimens detected the presence of diltiazem and pentoxifylline. Quantitations were carried out by gas chromatography using nitrogen-phosphorus detection and confirmed by gas chromatography-mass spectrometry with the following results: blood, 0.59 mg/dL diltiazem and 0.63 mg/dL pentoxifylline; urine, 1.17 mg/dt diltiazem and 0.08 mg/dL pentoxifylline; bile, 0.40 mg/dL diltiazem and 0.22 mg/dL pentoxifylline; gastric contents, 0.28 mg/dL diltiazem and 0.02 mg/dL pentoxifylline. Both drugs were found qualitatively in formalin-fixed tissues.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/21.7.576