Neurobehavioral Development of Neonatal Mice Following Blockade of VIP During the Early Embryonic Period

Wu, J. Y., K. A. Henins, P. Gressens, I. Gozes, M. Fridkin, D. E. Brenneman and J. M. Hill. Neurobehavioral development of neonatal mice following blockade of VIP during the early embryonic period. Peptides 18(8) 1131–1137, 1997.—Previous work has shown that blockade of VIP function in the early pos...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1997, Vol.18 (8), p.1131-1137
Main Authors: Wu, Joyce Y, Henins, Karin A, Gressens, Pierre, Gozes, Illana, Fridkin, Mati, Brenneman, Douglas E, Hill, Joanna M
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Behavior, Animal - drug effects
Behavior, Animal - physiology
Body Weight - drug effects
Body Weight - physiology
Developmental milestones
Developmental retardation
Embryonic and Fetal Development - drug effects
Embryonic and Fetal Development - physiology
Embryonic Development
Female
Growth Inhibitors - pharmacology
Mice
Motor Activity - drug effects
Motor Activity - physiology
Mouse embryos
Neurobehavioral development
Neurotensin - pharmacology
Pregnancy
Recombinant Fusion Proteins - pharmacology
Vasoactive intestinal peptide
Vasoactive Intestinal Peptide - antagonists & inhibitors
Vasoactive Intestinal Peptide - pharmacology
Vasoactive Intestinal Peptide - physiology
VIP antagonist
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Summary:Wu, J. Y., K. A. Henins, P. Gressens, I. Gozes, M. Fridkin, D. E. Brenneman and J. M. Hill. Neurobehavioral development of neonatal mice following blockade of VIP during the early embryonic period. Peptides 18(8) 1131–1137, 1997.—Previous work has shown that blockade of VIP function in the early postimplantation embryo results in growth retardation and microcephaly. In the present work, the neurobehavioral development of neonatal mice was examined following treatment of dams with a VIP antagonist during this period. Inhibition of VIP functions during early embryogenesis impaired the performance of 5 of 10 developmental behaviors. These behaviors included developmental milestones (first appearance of ear twitch and eye opening) and complex motor behaviors (negative geotaxis, surface righting, and air righting). The retardation of neurobehavioral development produced by inhibition of VIP action indicates that this peptide is important to the progression of embryonic development. Published by Elsevier Science Inc.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(97)00146-0