Immunosuppressive potential and pathogenicity of recent of isolate of infectious bursal disease virus in commercial broiler chickens

• Published in: Avian diseases 1989-10, Vol.33 (4), p.724-728
• Main Authors: Rosales, A.G. (University of Georgia, Athens, GA), Villegas, P, Fletcher, O.J, Brown, J
• Format: Article
• Language: English
• Subjects: Animals; ANTIBODIES; ANTICORPS; ANTICUERPOS; AVIAN INFECTIOUS BURSITIS; Body Weight; BOLSA DE FABRICIO; BOURSE DE FABRICIUS; BROILER CHICKENS; BURSA FABRICII; Chickens; Chickens - immunology; DISEASE RESISTANCE; edgar; ENFERMEDAD DE GUMBORO; ENFERMEDADES LINFATICAS; GROSSEUR; Immune Tolerance; IMMUNODEPRESSEUR; IMMUNOSUPPRESSANTS; Infections; Infectious bursal disease virus; Infectious bursal disease virus - immunology; Infectious bursal disease virus - pathogenicity; Infectious diseases; INMUNODEPRESORES; LYMPHATIC DISEASES; MALADIE DE GUMBORO; MALADIE DU SYSTEME LYMPHATIQUE; MATERNAL ANTIBODIES; Neutralization Tests; Newcastle disease; NEWCASTLE DISEASE VIRUS; Newcastle disease virus - physiology; Organ Size; PATHOGENICITY; PODER PATOGENO; POLLO DE ENGORDE; POULET DE CHAIR; POUVOIR PATHOGENE; Reoviridae - pathogenicity; Reoviridae Infections - etiology; Reoviridae Infections - veterinary; RESISTANCE AUX MALADIES; RESISTENCIA A LA ENFERMEDAD; SIZE; SPLENOMEGALY; STRAIN DIFFERENCES; TAMANO; u-28; Vaccination; Virulence; VIRUS; VIRUS DE LA ENFERMEDAD DE NEWCASTLE; VIRUS MALADIE DE NEWCASTLE; VIRUSES
• ISSN: 0005-2086; 1938-4351
• DOI: 10.2307/1591151

At 15 days of age and in the presence of measurable levels of maternal antibody against infectious bursal disease virus serotype I (1:170 virus-neutralization geometric mean titer), a recent isolate (U-28) and a prototype virulent isolate (Edgar) of the same virus caused subclinical infections in commercial broiler chickens. Isolate U-28 caused a significant reduction in the size of the bursa of Fabricius, whereas the Edgar isolate produced splenomegaly. Both isolates reduced the serological response to Newcastle disease virus. The experimental immunosuppressive potential and pathogenicity of isolate U-28 in broiler chickens confirms the role of this virus in recent infectious bursal disease outbreaks. /// Una cepa recientemente aislada del virus de la enfermedad infecciosa de la bolsa (Gumboro) designada como U-28 y una cepa virulenta prototipo del mismo virus conocida como cepa Edgar causaron infección subclínica en pollos de engorde infectados a los 15 días de edad. El promedio geométrico de los niveles de anticuerpos maternales contra Gumboro medidos en la prueba de virus neutralización era de 170. La cepa U-28 causó una reducción significante en el tamaño de la bolsa de Fabricio, mientras que la cepa Edgar causó esplecnomegalia. Ambas cepas redujeron la respuesta serológica contra el virus de la enfermedad de Newcastle. El potencial inmunosupresor y la patogenicidad de la cepa U-28 confirma el papel de este virus en los brotes recientes de la enfermedad infecciosa de la bolsa.