Treatment of Fungal Corneal Ulcers With Amphotericin B Ointment

To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment. Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2,...

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Bibliographic Details
Published in:American journal of ophthalmology 1997-12, Vol.124 (6), p.836-838
Main Authors: Hirose, Hiroshi, Terasaki, Hiroko, Awaya, Shinobu, Yasuma, Tetsushi
Format: Article
Language:English
Subjects:
Administration, Topical
Aged
Amphotericin B - administration & dosage
Amphotericin B - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Aspergillus fumigatus - isolation & purification
Biological and medical sciences
Cornea - microbiology
Corneal Injuries
Corneal Ulcer - drug therapy
Corneal Ulcer - microbiology
Corneal Ulcer - pathology
Eye Foreign Bodies - complications
Eye Foreign Bodies - microbiology
Eye Foreign Bodies - surgery
Eye Infections, Fungal - drug therapy
Eye Infections, Fungal - etiology
Eye Infections, Fungal - pathology
Female
Follow-Up Studies
Fusarium - isolation & purification
Humans
Male
Medical sciences
Middle Aged
Mycoses - drug therapy
Mycoses - etiology
Mycoses - pathology
Ointments
Pharmacology. Drug treatments
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Summary:To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment. Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration. Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers. Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycoticresistant fungi.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(14)71701-5