Compartmentally specific effects of quinpirole on the striatal Fos expression induced by stimulation of D1-dopamine receptors in intact rats

Injections of the full D1-agonist A-77636 (1.45 mg/kg) were found to induce clear Fos-like immunoreactivity (FLI) in the striatum of neurologically intact rats. Pretreatment with the D2-like agonist quinpirole (3 mg/kg) potentiated staining in the lateral striatum, but actually decreased the number...

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Bibliographic Details
Published in:Brain research 1997-10, Vol.771 (2), p.271-277
Main Authors: Wirtshafter, D, Schardt, G, Asin, K E
Format: Article
Language:English
Subjects:
Animals
Calbindins
Dopamine Agonists - pharmacology
Gene Expression - drug effects
Genes, fos - genetics
Immunohistochemistry
Male
Neostriatum - drug effects
Neostriatum - metabolism
Nerve Tissue Proteins - metabolism
Proto-Oncogene Proteins c-fos - biosynthesis
Proto-Oncogene Proteins c-fos - metabolism
Quinpirole - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 - drug effects
Receptors, Dopamine D1 - genetics
S100 Calcium Binding Protein G - metabolism
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Summary:Injections of the full D1-agonist A-77636 (1.45 mg/kg) were found to induce clear Fos-like immunoreactivity (FLI) in the striatum of neurologically intact rats. Pretreatment with the D2-like agonist quinpirole (3 mg/kg) potentiated staining in the lateral striatum, but actually decreased the number of immunoreactive cells observed in the medial portion of the rostral striatum. Comparison with adjacent sections processed for the calcium binding protein calbindin, indicated that quinpirole pretreatment specifically suppressed staining in the matrix compartment of the striatum while tending to potentiate it in the striosomes, resulting in an extremely patchy pattern of labeling. These results suggest that exogenous stimulation of D2-receptors, although not essential for the induction of FLI, may play an important role in the compartmental patterning of neuronal activity within the striatum.
ISSN:0006-8993
DOI:10.1016/S0006-8993(97)00795-6