Protective immunity against Angiostrongylus cantonensis in rats following sensitizing infections

Three strains (ACI, August and Wistar) of rats previously sensitized by oral infection with intact third-stage larvae of Angiostrongylus cantonensis developed significant protective immunity to challenge infections 6 weeks later. The degree of the immunity was highest in the August strain of rats, f...

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Bibliographic Details
Published in:Parasitology research (1987) 1989, Vol.76 (1), p.26-31
Main Authors: YOSHIMURA, K, ISHIDA, K, ISHIGOOKA, S, SUGAYA, H, KUMAGAI, M
Format: Article
Language:English
Subjects:
Angiostrongylus - immunology
Animals
Biological and medical sciences
Diseases caused by nematodes
Eosinophils - immunology
Female
Helminthic diseases
Infectious diseases
Larva - immunology
Male
Medical sciences
Miscellaneous
Nematode Infections - immunology
Nematode Infections - prevention & control
Parasitic diseases
Peritoneal Cavity - cytology
Rats
Rats, Inbred ACI
Rats, Inbred F344
Rats, Inbred Strains
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Summary:Three strains (ACI, August and Wistar) of rats previously sensitized by oral infection with intact third-stage larvae of Angiostrongylus cantonensis developed significant protective immunity to challenge infections 6 weeks later. The degree of the immunity was highest in the August strain of rats, followed by Wistar and ACI rats. Protective immunity appears to affect both third-stage larvae and fourth- and/or fifth-stage worms. ACI rats showed poor antibody responses, especially in the IgE fraction. When 24-day-old young adult worms were transferred from the brain of donor rats into the peritoneal cavity of sensitized rodents, peritoneal eosinophils predominantly adhered to the worm surfaces in vivo.
ISSN:0932-0113
1432-1955
DOI:10.1007/BF00931067