Urinary growth hormone: a screening test for growth hormone sufficiency

OBJECTIVES The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency. PATIENTS We studied (i) short statured children previously diagnosed as GH suffici...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 1997-10, Vol.47 (4), p.447-454
Main Authors: Butt, Debra A., Sochett, Etienne B.
Format: Article
Language:English
Subjects:
Adolescent
Analysis of Variance
Biological and medical sciences
Child
Child, Preschool
Female
Functional investigation of endocrine glands and genital system
Growth Disorders - diagnosis
Growth Disorders - urine
Growth Hormone - deficiency
Growth Hormone - urine
Humans
Immunoassay
Immunoenzyme Techniques
Investigative techniques, diagnostic techniques (general aspects)
Luminescent Measurements
Male
Medical sciences
Predictive Value of Tests
Regression Analysis
ROC Curve
Sensitivity and Specificity
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Summary:OBJECTIVES The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency. PATIENTS We studied (i) short statured children previously diagnosed as GH sufficient (n = 44) or GH deficient (n = 41) (peak serum GH ≥8 μg/l or 2.3 ng/m2). When this and other cut‐offs were applied to the test group, we found consistency between the observed and predicted numbers of GH sufficient and deficient subjects. CONCLUSIONS We conclude that urinary GH is a useful test for the diagnosis of GH sufficiency as defined by serum criteria and can be used to reduce significantly the number of serum stimulation tests.
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.1997.2821086.x