Auditory evoked potential index: a quantitative measure of changes in auditory evoked potentials during general anaesthesia

We describe a novel index derived from the auditory evoked potential, the auditory evoked potential index, and we compare it with latencies and amplitudes related to clinical signs of consciousness and unconsciousness. Eleven patients, scheduled for total knee replacement under spinal anaesthesia, c...

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Bibliographic Details
Published in:Anaesthesia 1997-11, Vol.52 (11), p.1030-1036
Main Authors: Mantzaridis, H., Kenny, G. N. C.
Format: Article
Language:English
Subjects:
Anaesthesia
depth
Anesthesia
Anesthesia, General
Anesthesia, Spinal
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Intravenous - pharmacology
Arthroplasty, Replacement, Knee
Biological and medical sciences
Consciousness - drug effects
Evoked Potentials, Auditory - drug effects
Evoked Potentials, Auditory - physiology
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Humans
Medical sciences
Monitoring, Intraoperative - methods
Monitoring
auditory evoked potential, auditory evoked potential index
Propofol - pharmacology
Reaction Time - drug effects
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Summary:We describe a novel index derived from the auditory evoked potential, the auditory evoked potential index, and we compare it with latencies and amplitudes related to clinical signs of consciousness and unconsciousness. Eleven patients, scheduled for total knee replacement under spinal anaesthesia, completed the study. The initial mean (SD) value of the auditory evoked potential index was 72.5 (11.2). During the first period of unconsciousness it decreased to 39.6 (6.9) and returned to 66.8 (12.5) when patients regained consciousness. Thereafter, similar values were obtained whenever patients lost and regained consciousness. Latencies and amplitudes changed in a similar fashion. From all parameters studied, Na latencies had the greatest overlap between successive awake and asleep states. The auditory evoked potential index and Nb latencies had no overlap. The consistent changes demonstrated suggest that the auditory evoked potential index could be used as a reliable indicator of potential awareness during propofol anaesthesia instead of latencies and amplitudes.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1997.185-az0327.x