Some aspects of the effects of PL-10.1.AK-15 on the gastrointestinal tract

PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physiology, Paris Paris, 1997-05, Vol.91 (3), p.179-181
Main Authors: Erceg, D, Simicevic, VN, Kolega, M, Dohoczky, Cs
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - pharmacology
body protection compound
Digestive System - drug effects
Digestive System - metabolism
Gastric Acid - secretion
Gastric Acidity Determination
gastrointestinal motility
Gastrointestinal Motility - drug effects
Humans
Male
Mice
Mice, Inbred Strains
Peptide Fragments - pharmacology
PL-10.1.AK-15
Proteins - pharmacology
Rats
Rats, Wistar
safety pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointestinal motility. Gastric acid secretion was assessed in male Wistar rats using a modified method of Shay, while gastrointestinal motility was assessed in male NMRI mice by charcoal propulsion. PL-10.1.AK-15 was given in three different doses (3, 10 and 100 μg/kg body weight) in accordance with the experimental protocol. The results of these experiments indicate that PL-10.1.AK-15 in the investigated doses had no influence on gastric acid secretion or gastrointestinal motility.
ISSN:0928-4257
1769-7115
DOI:10.1016/S0928-4257(97)89481-8