Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women

In a randomised, double-blind trial two single-dose regimens of ciprofloxacin were evaluated for treatment of acute urinary tract infection (UTI) in women. Fifty-three women received 250 mg and 46 750 mg of ciprofloxacin. Seven days after treatment the eradication rate was 81.1% and 82.6% in the low...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 1989-12, Vol.8 (12), p.1040-1042
Main Authors: Raz, R, Rottensterich, E, Hefter, H, Kennes, Y, Potasman, I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Ciprofloxacin - administration & dosage
Ciprofloxacin - therapeutic use
Double-Blind Method
Drug Administration Schedule
Drug Resistance, Microbial
Female
Humans
Middle Aged
Random Allocation
Recurrence
Time Factors
Urinary Tract Infections - drug therapy
Urinary Tract Infections - microbiology
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Summary:In a randomised, double-blind trial two single-dose regimens of ciprofloxacin were evaluated for treatment of acute urinary tract infection (UTI) in women. Fifty-three women received 250 mg and 46 750 mg of ciprofloxacin. Seven days after treatment the eradication rate was 81.1% and 82.6% in the low and high dose groups respectively; the clinical cure rate at 28 days was 64.1% and 73.9% respectively. In women with recurrent UTI a significantly better response was found with the high dose regimen (92% versus 68%; p less than 0.001). It is concluded that a single 250 mg dose of ciprofloxacin is effective for treatment in most women with acute UTI, but in women with recurrent infection a 750 mg dose is preferable.
ISSN:0934-9723
1435-4373
DOI:10.1007/BF01975166