Vagal and sympathetic influences on the ferret lower oesophageal sphincter

This study has investigated the relative involvement of cholinergic, adrenergic, nitric oxide and tachykininergic transmission in extrinsic neural influences on the lower oesophageal sphincter (LOS) in urethane anaesthetized ferrets. A micromanometric assembly (OD 1.75 mm) incorporating a sleeve sen...

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Bibliographic Details
Published in:Journal of the autonomic nervous system 1997-10, Vol.66 (3), p.179-188
Main Authors: Blackshaw, L.A, Haupt, J.A, Omari, T, Dent, J
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - administration & dosage
Adrenergic alpha-Agonists - pharmacology
Animals
Biological and medical sciences
Electric Stimulation
Esophagogastric Junction - drug effects
Esophagogastric Junction - innervation
Female
Ferrets - physiology
Fundamental and applied biological sciences. Psychology
Gastroesophageal Reflux - physiopathology
Injections, Intra-Arterial
Male
Manometry
Neurotransmitter Agents - pharmacology
Neurotransmitter Agents - physiology
Norepinephrine - administration & dosage
Norepinephrine - pharmacology
Receptors, Tachykinin - antagonists & inhibitors
Sphincter
Splanchnic nerve
Splanchnic Nerves - physiology
Stomach
Substance P - metabolism
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Tachykinin receptors
Vagus nerve
Vagus Nerve - drug effects
Vagus Nerve - physiology
Vertebrates: digestive system
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Summary:This study has investigated the relative involvement of cholinergic, adrenergic, nitric oxide and tachykininergic transmission in extrinsic neural influences on the lower oesophageal sphincter (LOS) in urethane anaesthetized ferrets. A micromanometric assembly (OD 1.75 mm) incorporating a sleeve sensor was used for high-fidelity oesophageal, LOS and gastric pressure measurement at low perfusion rates (
ISSN:0165-1838
1872-7476
DOI:10.1016/S0165-1838(97)00082-9