Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke

Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We re...

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Bibliographic Details
Published in:The Journal of pediatrics 1997-11, Vol.131 (5), p.757-760
Main Authors: Rana, Sohail, Houston, Patricia E., Surana, Narita, Shalaby-Rana, Eglal I., Castro, Oswaldo L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - therapy
Anemias. Hemoglobinopathies
Biological and medical sciences
Blood Transfusion
Cerebral Infarction - blood
Cerebral Infarction - etiology
Child
Diseases of red blood cells
Follow-Up Studies
Hematologic and hematopoietic diseases
Hemoglobin, Sickle - metabolism
Humans
Medical sciences
Time Factors
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Summary:Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We report on nine consecutive patients with sickle cell disease and stroke whose long-term transfusion therapy was discontinued and in whom no ischemic strokes developed during 80.75 patient years of follow-up. (J Pediatr 1997;131:757-60)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(97)70108-2