Loading…

Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke

Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We re...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of pediatrics 1997-11, Vol.131 (5), p.757-760
Main Authors:	Rana, Sohail, Houston, Patricia E., Surana, Narita, Shalaby-Rana, Eglal I., Castro, Oswaldo L.
Format:	Article
Language:	English
Subjects:	Adolescent Adult Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Anemia, Sickle Cell - therapy Anemias. Hemoglobinopathies Biological and medical sciences Blood Transfusion Cerebral Infarction - blood Cerebral Infarction - etiology Child Diseases of red blood cells Follow-Up Studies Hematologic and hematopoietic diseases Hemoglobin, Sickle - metabolism Humans Medical sciences Time Factors
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423
cites	cdi_FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423
container_end_page	760
container_issue	5
container_start_page	757
container_title	The Journal of pediatrics
container_volume	131
creator	Rana, Sohail Houston, Patricia E. Surana, Narita Shalaby-Rana, Eglal I. Castro, Oswaldo L.
description	Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We report on nine consecutive patients with sickle cell disease and stroke whose long-term transfusion therapy was discontinued and in whom no ischemic strokes developed during 80.75 patient years of follow-up. (J Pediatr 1997;131:757-60)
doi_str_mv	10.1016/S0022-3476(97)70108-2
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79473556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347697701082</els_id><sourcerecordid>79473556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423</originalsourceid><addsrcrecordid>eNqFkc9vFCEUx4mxqdvVP6EJB2P0MAoDw4-TaarVJk08qGdk4I3FzsIKjE3_e9nuZq89vYT3gfd9HxA6p-Q9JVR8-E5I33eMS_FWy3eSUKK6_hlaUaJlJxRjz9HqiLxAZ6X8IYRoTsgpOm2FCUFX6NenUFyKNcTF1pAiThOeU_zdVcgbXLONZVrKrlFvIdvtAw4RbxsKsRZ8H-otLsHdzYAdzDP2oYAtgG30uNSc7uAlOpnsXODVoa7Rz6vPPy6_djffvlxfXtx0jlNVOwnjpDxMDAQftPZKKEV1P2oJk2ZyZMJJwjinfhRqHKgm3FLlB9GrdsJ7tkZv9u9uc_q7QKlm0zZrmWyEtBQjNZdsGEQDhz3ociolw2S2OWxsfjCUmJ1Z82jW7LQZLc2jWbMbcH4YsIwb8MdbB5Wt__rQt8XZeWrqXChHrG__olqENfq4x6DJ-Bcgm-KaTAc-ZHDV-BSeCPIfRnyVnA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79473556</pqid></control><display><type>article</type><title>Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke</title><source>ScienceDirect Journals</source><creator>Rana, Sohail ; Houston, Patricia E. ; Surana, Narita ; Shalaby-Rana, Eglal I. ; Castro, Oswaldo L.</creator><creatorcontrib>Rana, Sohail ; Houston, Patricia E. ; Surana, Narita ; Shalaby-Rana, Eglal I. ; Castro, Oswaldo L. ; The Departments of Radiology and Pediatrics, Children’s National Medical Center and George Washington University Medical Center, Washington, D.C ; From the Departments of Medicine and Pediatrics, Howard University College of Medicine, Washington, D.C</creatorcontrib><description>Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We report on nine consecutive patients with sickle cell disease and stroke whose long-term transfusion therapy was discontinued and in whom no ischemic strokes developed during 80.75 patient years of follow-up. (J Pediatr 1997;131:757-60)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(97)70108-2</identifier><identifier>PMID: 9403661</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - therapy ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Blood Transfusion ; Cerebral Infarction - blood ; Cerebral Infarction - etiology ; Child ; Diseases of red blood cells ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Hemoglobin, Sickle - metabolism ; Humans ; Medical sciences ; Time Factors</subject><ispartof>The Journal of pediatrics, 1997-11, Vol.131 (5), p.757-760</ispartof><rights>1997 Mosby, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423</citedby><cites>FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2109847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9403661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rana, Sohail</creatorcontrib><creatorcontrib>Houston, Patricia E.</creatorcontrib><creatorcontrib>Surana, Narita</creatorcontrib><creatorcontrib>Shalaby-Rana, Eglal I.</creatorcontrib><creatorcontrib>Castro, Oswaldo L.</creatorcontrib><creatorcontrib>The Departments of Radiology and Pediatrics, Children’s National Medical Center and George Washington University Medical Center, Washington, D.C</creatorcontrib><creatorcontrib>From the Departments of Medicine and Pediatrics, Howard University College of Medicine, Washington, D.C</creatorcontrib><title>Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We report on nine consecutive patients with sickle cell disease and stroke whose long-term transfusion therapy was discontinued and in whom no ischemic strokes developed during 80.75 patient years of follow-up. (J Pediatr 1997;131:757-60)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - therapy</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Cerebral Infarction - blood</subject><subject>Cerebral Infarction - etiology</subject><subject>Child</subject><subject>Diseases of red blood cells</subject><subject>Follow-Up Studies</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobin, Sickle - metabolism</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Time Factors</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkc9vFCEUx4mxqdvVP6EJB2P0MAoDw4-TaarVJk08qGdk4I3FzsIKjE3_e9nuZq89vYT3gfd9HxA6p-Q9JVR8-E5I33eMS_FWy3eSUKK6_hlaUaJlJxRjz9HqiLxAZ6X8IYRoTsgpOm2FCUFX6NenUFyKNcTF1pAiThOeU_zdVcgbXLONZVrKrlFvIdvtAw4RbxsKsRZ8H-otLsHdzYAdzDP2oYAtgG30uNSc7uAlOpnsXODVoa7Rz6vPPy6_djffvlxfXtx0jlNVOwnjpDxMDAQftPZKKEV1P2oJk2ZyZMJJwjinfhRqHKgm3FLlB9GrdsJ7tkZv9u9uc_q7QKlm0zZrmWyEtBQjNZdsGEQDhz3ociolw2S2OWxsfjCUmJ1Z82jW7LQZLc2jWbMbcH4YsIwb8MdbB5Wt__rQt8XZeWrqXChHrG__olqENfq4x6DJ-Bcgm-KaTAc-ZHDV-BSeCPIfRnyVnA</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Rana, Sohail</creator><creator>Houston, Patricia E.</creator><creator>Surana, Narita</creator><creator>Shalaby-Rana, Eglal I.</creator><creator>Castro, Oswaldo L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke</title><author>Rana, Sohail ; Houston, Patricia E. ; Surana, Narita ; Shalaby-Rana, Eglal I. ; Castro, Oswaldo L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - therapy</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>Cerebral Infarction - blood</topic><topic>Cerebral Infarction - etiology</topic><topic>Child</topic><topic>Diseases of red blood cells</topic><topic>Follow-Up Studies</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobin, Sickle - metabolism</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rana, Sohail</creatorcontrib><creatorcontrib>Houston, Patricia E.</creatorcontrib><creatorcontrib>Surana, Narita</creatorcontrib><creatorcontrib>Shalaby-Rana, Eglal I.</creatorcontrib><creatorcontrib>Castro, Oswaldo L.</creatorcontrib><creatorcontrib>The Departments of Radiology and Pediatrics, Children’s National Medical Center and George Washington University Medical Center, Washington, D.C</creatorcontrib><creatorcontrib>From the Departments of Medicine and Pediatrics, Howard University College of Medicine, Washington, D.C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rana, Sohail</au><au>Houston, Patricia E.</au><au>Surana, Narita</au><au>Shalaby-Rana, Eglal I.</au><au>Castro, Oswaldo L.</au><aucorp>The Departments of Radiology and Pediatrics, Children’s National Medical Center and George Washington University Medical Center, Washington, D.C</aucorp><aucorp>From the Departments of Medicine and Pediatrics, Howard University College of Medicine, Washington, D.C</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>131</volume><issue>5</issue><spage>757</spage><epage>760</epage><pages>757-760</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Long-term transfusion therapy in patients with sickle cell disease and stroke markedly decreases the risk of stroke recurrence. However, it is not known how long the transfusions should be continued. Published reports have documented a high risk of stroke recurrence after stopping transfusion. We report on nine consecutive patients with sickle cell disease and stroke whose long-term transfusion therapy was discontinued and in whom no ischemic strokes developed during 80.75 patient years of follow-up. (J Pediatr 1997;131:757-60)</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9403661</pmid><doi>10.1016/S0022-3476(97)70108-2</doi><tpages>4</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0022-3476
ispartof	The Journal of pediatrics, 1997-11, Vol.131 (5), p.757-760
issn	0022-3476 1097-6833
language	eng
recordid	cdi_proquest_miscellaneous_79473556
source	ScienceDirect Journals
subjects	Adolescent Adult Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Anemia, Sickle Cell - therapy Anemias. Hemoglobinopathies Biological and medical sciences Blood Transfusion Cerebral Infarction - blood Cerebral Infarction - etiology Child Diseases of red blood cells Follow-Up Studies Hematologic and hematopoietic diseases Hemoglobin, Sickle - metabolism Humans Medical sciences Time Factors
title	Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T23%3A11%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discontinuation%20of%20long-term%20transfusion%20therapy%20in%20patients%20with%20sickle%20cell%20disease%20and%20stroke&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Rana,%20Sohail&rft.aucorp=The%20Departments%20of%20Radiology%20and%20Pediatrics,%20Children%E2%80%99s%20National%20Medical%20Center%20and%20George%20Washington%20University%20Medical%20Center,%20Washington,%20D.C&rft.date=1997-11-01&rft.volume=131&rft.issue=5&rft.spage=757&rft.epage=760&rft.pages=757-760&rft.issn=0022-3476&rft.eissn=1097-6833&rft.coden=JOPDAB&rft_id=info:doi/10.1016/S0022-3476(97)70108-2&rft_dat=%3Cproquest_cross%3E79473556%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c418t-7ebf8def3e64599d8688192b97ef937b36c703441db68b51904a18d5628db6423%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=79473556&rft_id=info:pmid/9403661&rfr_iscdi=true