Ribonuclease inhibits Kaposi's sarcoma

Kaposi's sarcoma (KS) is a cancer closely associated with AIDS. Crude, commercial human urinary chorionic gonadotrophin (hCG) preparations have previously been found to inhibit the growth of KS cell lines in vitroand in immunodeficient mice,, and to induce tumour regression of KS lesions in AID...

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Bibliographic Details
Published in:Nature (London) 1997-12, Vol.390 (6660), p.568-568
Main Authors: Griffiths, Suzanne J, Adams, David J, Talbot, Simon J
Format: Article
Language:English
Subjects:
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Apoptosis
Cancer
Chorionic Gonadotropin - chemistry
Contaminants
Drug Screening Assays, Antitumor
Enzymes
HeLa Cells
Humanities and Social Sciences
Humans
Kaposis sarcoma
multidisciplinary
Proteins
Ribonucleases - isolation & purification
Ribonucleases - pharmacology
Ribonucleases - urine
Sarcoma
Sarcoma, Kaposi - drug therapy
Science
scientific-correspondence
Tumor Cells, Cultured
Tumors
X chromosomes
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Summary:Kaposi's sarcoma (KS) is a cancer closely associated with AIDS. Crude, commercial human urinary chorionic gonadotrophin (hCG) preparations have previously been found to inhibit the growth of KS cell lines in vitroand in immunodeficient mice,, and to induce tumour regression of KS lesions in AIDS patients,. Here we report the purification of a ribonuclease (RNase) from a commercial hCG preparation. The pure enzyme killed KS cells in vitro,apparently by apoptosis, suggesting that effects of commercial hCG preparations on KS cells and tumours are due, at least in part, to RNase present as a contaminant in these preparations.
ISSN:0028-0836
1476-4687
DOI:10.1038/37510