Phase II clinical trial of a vas deferens injectable contraceptive for the male

Following up on an earlier clinical trial demonstrating the safety of an intra-vas deferens injection of a contraceptive drug named Risug, comprised of styrene maleic anhydride (SMA) in a solvent vehicle of dimethylsulphoxide (DMSO), a study to assess the contraceptive effectiveness of a specific do...

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Bibliographic Details
Published in:Contraception (Stoneham) 1997-10, Vol.56 (4), p.245-250
Main Authors: Guha, Sujoy K., Singh, Gulshanjit, Ansari, Shirfuddin, Kumar, Sudheer, Srivastava, Anil, Koul, Veena, Das, H.C., Malhotra, R.L., Das, S.K.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Contraceptive Agents, Male - administration & dosage
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
injectable male contraceptive
Injections - methods
Male
Maleic Anhydrides - administration & dosage
Medical sciences
Oligospermia
Other methods of contraception. Sterilization
Polystyrenes - administration & dosage
Population
pregnancy protection
Spermatozoa - drug effects
styrene maleic anhydride
Vas Deferens
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Summary:Following up on an earlier clinical trial demonstrating the safety of an intra-vas deferens injection of a contraceptive drug named Risug, comprised of styrene maleic anhydride (SMA) in a solvent vehicle of dimethylsulphoxide (DMSO), a study to assess the contraceptive effectiveness of a specific dose (60 mg) of SMA bilaterally was planned and implemented. Male subjects and their wives with normal reproductive profiles were the volunteer subjects. The wives were not using any contraceptives. The results reconfirm the safety and show that for a period of at least 1 year, the treatment leads to azoospermia in the male and gives pregnancy protection.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(97)00142-X